Time extrapolation factors for risk assessment: are group specific extrapolation factors possible? (eTOXV)

Abstract

In risk assessment time extrapolationfactors (EFs) are used when a short time study is available, but chronic exposure needs to be considered.
Probabilistic analyses are needed to substantiate current EFs by exploring large experimental datasets.
EFs were derived from paired studies, each representing the ratio of the long term study NOEL divided by the short term study NOEL